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Related Experiment Videos

Sinusoidal crossflow microfiltration device--experimental and computational flowfield analysis.

Michal M Mielnik1, Rahul P Ekatpure, Lars R Saetran

  • 1Norwegian University of Science and Technology, Department of Energy and Process Engineering, Kolbjorn Hejes vei 2, N-7491 Trondheim, Norway. michal.mielnik@ntnu.no

Lab on a Chip
|July 20, 2005
PubMed
Summary

A novel corrugated microfiltration device enhances shear focusing, increasing wall shear rates by 55-85%. This may reduce clogging and improve performance in lab-on-a-chip applications.

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Area of Science:

  • Fluid dynamics
  • Microfluidics
  • Biochemical engineering

Background:

  • Crossflow microfiltration is crucial for separating biological entities.
  • Conventional devices often suffer from clogging and cell cake formation.
  • Optimizing flow dynamics can enhance microfiltration efficiency.

Purpose of the Study:

  • To analyze the flowfield within a novel corrugated crossflow microfiltration device.
  • To investigate the impact of channel geometry on shear stress and flow characteristics.
  • To evaluate the potential of this device for improved microfiltration performance.

Main Methods:

  • Micro Particle Image Velocimetry (micro-PIV) for experimental flow visualization.
  • Computational Fluid Dynamics (CFD) for numerical simulation of fluid behavior.

Related Experiment Videos

  • Analysis of flow and shear stress within a corrugated channel geometry.

    • Main Results:

    • Achieved a 55-85% increase in shear rate compared to straight channels.
    • Observed significant shear focusing due to the corrugated channel design.
    • Demonstrated effective flow characteristics for crossflow velocities from 0.05-0.8 m/s (Re 5-70).

    Conclusions:

    • The corrugated channel design substantially increases local wall shear, potentially reducing filter clogging.
    • The device offers a technically and economically feasible solution for integrated lab-on-a-chip systems.
    • Shear-focusing principles may benefit other biochemical applications like cell lysis and surface chemistry.