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[Gamma knife radiosurgery for large trigeminal schwannomas]
En-min Wang1, Li Pan, Bin-jiang Wang
1Department of Neurosurgery and Gamma Knife Center, Huashan Hospital, Fudan University, Shanhai, China.
Zhonghua Yi Xue Za Zhi
|July 21, 2005
Summary
Gamma Knife (GK) radiosurgery effectively controls large trigeminal schwannomas in 90% of patients. This treatment offers a viable alternative for select patients with tumors up to 40 mm, showing significant tumor volume reduction and symptom improvement.
Area of Science:
- Neurosurgery
- Radiation Oncology
Context:
- Large trigeminal schwannomas present significant treatment challenges.
- Gamma Knife (GK) radiosurgery is an advanced stereotactic radiation technique.
Purpose:
- To evaluate the efficacy of GK radiosurgery in managing large trigeminal schwannomas.
- To assess tumor control rates and clinical outcomes following GK treatment.
Summary:
- This study analyzed 30 patients with large trigeminal schwannomas treated with GK radiosurgery.
- A 90% tumor-growth control rate was achieved, with significant tumor volume reduction in 20 patients and neurological deficit improvement in 24.
- Histopathological examination of a resected tumor post-GK revealed extensive tumor necrosis.
Impact:
- GK radiosurgery demonstrates a high tumor-growth control rate for large trigeminal schwannomas.
- It offers a potentially less invasive treatment option compared to microsurgery for select patients.
- The findings support GK as a valuable therapeutic choice for specific large trigeminal schwannoma cases.