Potential for osseous regeneration of platelet-rich plasma--a comparative study in mandibular third molar sockets

Platelet-rich plasma (PRP), the concentrate of platelets in plasma contains various growth factors that enhance osseous regeneration. This study utilized homologous platelet-rich plasma in the treatment of third molar extraction sockets in a total of fourteen human subjects, who were randomly assigned into one control and one test group, each comprising of seven members. Clinical parameters like pain on palpation, number of analgesic tablets consumed, swelling, degree of mouth opening, and condition of mucosa overlying the surgical site were assessed at intervals of 1,3,5,7,9,12, and 16 weeks post operatively. The margins between the socket and surrounding bone, radiopacity of bone filling the socket, and presence oftrabecular bone formation were evaluated simultaneously. Soft tissue healing differed significantly between the two groups, with the test group exhibiting better results. Radiographic evidence of bone formation was visible as early as I week in test subjects. It was concluded that PRP contributed to better healing of soft tissues and bone and is a viable means of growth factor delivery.