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Related Experiment Videos

Diabetic diarrhea. An underdiagnosed complication?

D K Beebe1, E Walley

  • 1Department of Family Medicine, University of Mississippi School of Medicine, Jackson 39216.

Postgraduate Medicine
|June 1, 1992
PubMed
Summary

Diabetic diarrhea, often underestimated, may stem from nerve damage affecting gut motility. Treatments offer moderate relief, with newer options showing promise but potential side effects.

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Diabetology

Background:

  • Diarrhea is a frequent, yet underestimated, gastrointestinal complication in diabetic patients.
  • The exact etiology of diabetic diarrhea remains unclear, but is hypothesized to involve gastrointestinal motility disturbances linked to diabetic autonomic neuropathy.

Purpose of the Study:

  • To review the causes, diagnosis, and management of diarrhea in patients with diabetes mellitus.
  • To highlight the underrecognized prevalence and potential pathophysiology of diabetic diarrhea.

Main Methods:

  • Literature review of studies investigating diabetic diarrhea.
  • Analysis of potential causes including autonomic neuropathy, malabsorption, and endocrine tumors.
  • Evaluation of current and emerging treatment strategies for diabetic diarrhea.

Main Results:

  • Diabetic diarrhea is likely associated with autonomic neuropathy affecting gut motility.
  • Exclusion of other causes like malabsorption syndromes and islet cell tumors is crucial.
  • Symptomatic treatment with antidiarrheal agents provides temporary relief.
  • Long-term management options include broad-spectrum antibiotics and clonidine hydrochloride.
  • Somatostatin analogues show recent promise for treatment, with drowsiness and vomiting as notable side effects.

Conclusions:

  • Diabetic diarrhea requires careful diagnosis to rule out other conditions.
  • Management strategies vary from symptomatic relief to targeted therapies.
  • Emerging treatments like somatostatin analogues offer new therapeutic avenues for diabetic diarrhea.

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