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Related Experiment Videos

Cluster headache pharmacotherapy.

Brian E McGeeney1

  • 1Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. bmcg@bu.edu

American Journal of Therapeutics
|July 26, 2005
PubMed
Summary
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Cluster headache, a rare primary headache disorder, involves severe unilateral pain and autonomic symptoms. This review details its pharmacologic treatment, differentiating it from migraine.

Area of Science:

  • Neurology
  • Headache Medicine

Background:

  • Cluster headache is a distinct primary headache disorder, less common than migraine, affecting approximately 5/10,000 adults.
  • Historically known by terms like histaminic cephalalgia, it presents with brief, excruciating unilateral pain and autonomic features, typically during cluster periods lasting weeks.
  • Unlike migraine, cluster headache predominantly affects older males and responds differently to medications.

Purpose of the Study:

  • To review the pharmacologic treatment of cluster headache.
  • To differentiate cluster headache from migraine based on clinical and pathophysiologic features.
  • To outline both abortive and prophylactic treatment strategies for cluster headache.

Main Methods:

  • Review of existing literature on cluster headache pharmacologic treatment.

Related Experiment Videos

  • Comparison of cluster headache with migraine regarding clinical presentation and treatment response.
  • Categorization of treatments into abortive and prophylactic therapies.

    • Main Results:

    • Pharmacologic management is divided into acute attack treatment (abortive) and long-term remission induction (prophylactic).
    • Various medications exist for both treatment types, with varying levels of evidence.
    • Interventional procedures targeting the trigeminal nerve or ganglia serve as a last resort for refractory cases.

    Conclusions:

    • Most cluster headache patients can be managed effectively with medical therapy.
    • Prophylactic treatment aims to induce and maintain remission periods.
    • Interventional procedures offer an alternative for treatment-resistant patients.