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Primary intraocular T-cell-rich large B-cell lymphoma
Thomas J Cummings1, Timothy T Stenzel, Gordon Klintworth
1Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. cummi008@mc.duke.edu
Archives of Pathology & Laboratory Medicine
|July 29, 2005
Summary
A rare T-cell-rich large B-cell lymphoma was found in the eye. This diagnosis was confirmed after multiple procedures for presumed panuveitis, emphasizing careful cytologic interpretation.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Primary intraocular lymphomas are rare, often presenting with non-specific symptoms.
- A 57-year-old woman presented with symptoms suggestive of panuveitis, leading to multiple diagnostic vitrectomies.
Observation:
- The patient experienced vision loss in her left eye, necessitating enucleation.
- Histopathologic and immunohistochemical analyses of the enucleated globe were performed.
Findings:
- A diagnosis of primary intraocular large B-cell lymphoma involving the choroid, vitreous, and retina was established.
- The lymphoma was characterized by a significant population of T cells alongside neoplastic B cells.
- Molecular studies confirmed a monoclonal B-cell population and a polyclonal T-cell population.
Implications:
- This case underscores the importance of considering rare diagnoses like intraocular lymphoma in cases of persistent or atypical uveitis.
- Accurate cytologic interpretation of vitreous aspirates within the clinical context is crucial for timely diagnosis and management of intraocular malignancies.