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Antithrombotic activity of verapamil
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|January 1, 1992
Summary
Verapamil demonstrates significant antithrombotic effects by prolonging clotting time in arterial thrombosis models and reducing thrombus weight in ex vivo tests. This study highlights verapamil
Area of Science:
- Pharmacology
- Cardiovascular Research
- Thrombosis Studies
Background:
- Thrombosis poses a significant risk for cardiovascular events.
- Understanding the antithrombotic potential of existing drugs is crucial for therapeutic advancements.
Purpose of the Study:
- To evaluate the antithrombotic activity of verapamil (Ver).
- To assess verapamil's effects in both arterial and ex vivo thrombosis models.
Main Methods:
- Arterial thrombosis model in rat carotid artery using electric stimulation.
- Ex vivo thrombosis model to measure thrombus weight.
- Administration of verapamil at varying doses (2 and 4 mg.kg-1 ip; 0.2 mg.kg-1 iv).
- Assessment of blood viscosity.
Main Results:
- Verapamil (2 and 4 mg.kg-1 ip) significantly prolonged the time to thrombotic occlusion in the rat carotid artery.
- Verapamil (0.2 mg.kg-1 iv) reduced the weight of ex vivo thrombus formation.
- Verapamil did not affect blood viscosity.
Conclusions:
- Verapamil exhibits notable antithrombotic properties in preclinical models.
- The drug's mechanism may involve direct effects on thrombus formation rather than blood viscosity modification.