[Functional state of hypophysial-thyroid system of newborns with intrauterine infection]

The goal of our investigation was the study the functional state of hypophysial-thyroid hormonal axis in newborns during intrauterine infection, as well as to establish the specificity, sensitivity, prognostic and diagnostic values of thyroid hormones in the development of neonatal sepsis. On the basis of correlative analysis relationship between the clinically manifested intrauterine infection and the change in the concentration of thyroid hormones have been revealed. Particularly, decrease of the concentration of triiodothyronine (r=0,322, p<0,002) and thyroxin (r=0,298, p<0,004), as well as increase of thyrotropic hormone concentration (r=0,269, p<0,001) testify to a highly significant correlation between these changes. So, proceeding from our investigations it is possible it may be concluded:--Existence of changes in the concentrations of thyroid hormones in umbilical blood increases the risk of development of newborn sepsis.--Decrease of concentrations of T(3) and T(4) and increase of TSH concentration in umbilical blood of newborns in the high-risk group has a significant correlation with the development of sepsis in newborns.--Decrease of T(3) and T(4) concentrations in umbilical blood of newborns appears to be a high-specific and low-sensitive marker for the development of neonatal sepsis. Prognostic value of the positive result is high enough, while prognostic value of the negative result and diagnostic precision of above-mentioned tests appear to be moderate.--Increase of TSH concentration in umbilical blood is highly sensitive and low-specific marker for the development of neonatal sepsis, prognostic precision of the positive result is moderate, while of the negative result - high. Diagnostic precision of the test is average.--High concentration of thyrotropic hormone may be used as prognostic marker of neonatal sepsis outcome.