Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reproducing cardiac restitution properties using the Fenton-Karma membrane model.

Robert A Oliver1, Wanda Krassowska

  • 1Department of Biomedical Engineering, Duke University, P.O. Box 90281, Durham, NC 27708, USA. robert.oliver@duke.edu

Annals of Biomedical Engineering
|August 3, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Airway macrophage-intrinsic TGF-β1 regulates pulmonary immunity during early-life allergen exposure.

The Journal of allergy and clinical immunology·2021
Same author

Pulmonary Group 2 Innate Lymphoid Cell Phenotype Is Context Specific: Determining the Effect of Strain, Location, and Stimuli.

Frontiers in immunology·2020
Same author

A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma.

The Journal of allergy and clinical immunology·2019
Same author

Impact of Fire Arms Training in a Virtual Reality Environment on Occupational Performance (Marksmanship) in a Polytrauma Population.

Military medicine·2019
Same author

Functional Capacity Evaluation-Military: Program Description and Case Series.

Military medicine·2017
Same author

Period-doubling bifurcation to alternans in paced cardiac tissue: crossover from smooth to border-collision characteristics.

Physical review letters·2007
Same journal

Patient-Specific Adaptation of a Mechano-Regulatory Bone-Healing Model Using Longitudinal Loading Data.

Annals of biomedical engineering·2026
Same journal

Effects of Simulated Body-Mass Reduction on Peak Knee Joint Loads During Daily Functional Activities.

Annals of biomedical engineering·2026
Same journal

Evaluating Different Optimization Criteria for Estimating Spine Loads and Muscle Activity During Manual Lifting With and Without Assistance from Back-Support Exoskeletons.

Annals of biomedical engineering·2026
Same journal

A Physiologic Left Ventricle Flow Phantom for 4D Flow MRI Applications and CFD Verification.

Annals of biomedical engineering·2026
Same journal

Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.

Annals of biomedical engineering·2026
Same journal

A Pressure Difference-Based Strategy for Blood Oxygen Control in Membrane Oxygenators: Reduced Modeling, Computational Simulation, and Exploratory In Vivo Evaluation.

Annals of biomedical engineering·2026
See all related articles

This study simplifies complex cardiac membrane models for efficient simulations. Researchers optimized the Fenton-Karma (FK3V) model to accurately replicate atrial tissue restitution properties.

Area of Science:

  • Computational biology
  • Cardiac electrophysiology

Background:

  • Complex cardiac membrane models are computationally expensive for long simulations.
  • Simpler models are needed to preserve essential features of complex models.

Purpose of the Study:

  • To develop an empirical procedure for parameterizing a simplified cardiac membrane model.
  • To reproduce the restitution properties of a complex atrial tissue model using a simpler model.

Main Methods:

  • Empirical parameter selection for the three-variable Fenton-Karma (FK3V) model.
  • Comparison with the Courtemanche-Ramirez-Nattel (CRN) model of atrial tissue.

Main Results:

  • Optimized FK3V model parameters are provided.
  • A sensitivity table detailing the effect of FK3V parameters on restitution properties is presented.

Related Experiment Videos

Conclusions:

  • The study offers insights into the behavior of the FK3V model.
  • The optimized FK3V model serves as a computationally efficient alternative for simulating cardiac tissue restitution.