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Related Experiment Videos

Tumor necrosis factor-alpha and neuronal development.

Alain Bessis1, Delphine Bernard, Antoine Triller

  • 1Laboratoire de Biologie Cellulaire de la Synapse Normale et Pathologique, INSERM U497 Ecole Normale Supérieure, Paris, France. alain.bessis@ens.fr

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|August 3, 2005
PubMed
Summary
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Tumor necrosis factor-alpha (TNFalpha) drives neuronal cell death during development. Understanding these early mechanisms may reveal new therapies for neurodegenerative diseases in adults.

Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Biology

Background:

  • Tumor necrosis factor-alpha (TNFalpha), a key inflammatory cytokine, is elevated in neurodegenerative diseases.
  • While its role in adult brains is variable, TNFalpha's function in developmental neuronal death is less understood.

Purpose of the Study:

  • To investigate the role of TNFalpha in developmental neuronal cell death.
  • To explore the mechanisms by which TNFalpha induces cell death in developing neurons.

Main Methods:

  • Studies on sympathetic and trigeminal neurons.
  • Analysis of TNFalpha production by macrophages in the spinal cord.

Main Results:

  • TNFalpha induces immediate cell death in sympathetic and trigeminal neurons upon neurotrophic factor deprivation.

Related Experiment Videos

  • In spinal cord development, TNFalpha primes motoneurons for delayed cell death.

    • Conclusions:

    • TNFalpha plays a critical role in both immediate and delayed neuronal cell death during development.
    • Insights from embryonic systems offer potential therapeutic strategies for adult neurodegenerative conditions.