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A function for the macrophage F4/80 molecule in tolerance induction

Timo K van den Berg1, Georg Kraal

  • 1Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. t.vandenberg@vumc.nl

Trends in Immunology
|August 10, 2005
PubMed

The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?

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