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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Prednicarbate (Dermatop): profile of a corticosteroid
1Division of Dermatology, Department of Medicine, Sunnybrook and Women's College Health Science Center, Sunnybrook site and the University of Toronto, Toronto, Canada. agupta@execulink.com
Journal of Cutaneous Medicine and Surgery
|August 11, 2005
Summary
Prednicarbate offers a favorable benefit-risk profile for treating dermatoses, with low skin atrophy potential and high anti-inflammatory action. It is an ideal alternative for vulnerable patient groups requiring long-term treatment.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Topical steroids are widely used for cutaneous disorders.
- Adverse events like skin atrophy and HPA axis suppression limit their use.
Purpose of the Study:
- Review prednicarbate's mechanism of action.
- Evaluate its clinical efficacy and adverse events profile.
Main Methods:
- Literature search for studies on prednicarbate.
- Summarization of findings.
Main Results:
- Prednicarbate is a nonhalogenated, double-ester prednisolone derivative.
- Effective for inflammatory and pruritic dermatoses like atopic dermatitis.
- Demonstrates a favorable benefit-risk ratio, low skin atrophy potential, and high anti-inflammatory action.
Conclusions:
- Prednicarbate is suitable for children and the elderly.
- An ideal alternative for long-term intermittent treatment.
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