Investigations on some pharmacological properties of TPP

The experiments were performed on mice, rats and rabbits. The influence on circulatory, central nervous, and gastrointestinal system in vivo and in vitro, as well as on renal secretory activity was examined. TPP was administered p.o., i.v. and s.c. at the doses 100.0-400.0 mg/kg. Either in a single dose or multiple doses TPP did not evoke any significant effects (as compared with NaCl solution) on blood pressure, heart and respiratory rate, general behaviour, locomotor activity, body temperature, locomotor coordination, ECoG, smooth muscles of intestine in vivo and in vitro, gastric secretion and on the volume and quality of excreted urine. The augmentation of sodium and potassium ion excretion with urine and slight influence on locomotor coordination both after TPP and 6% NaCl seems to be connected with a high content of salt in TPP.