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Updated: Aug 16, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Efficient stereochemical controllers in biaryl Suzuki coupling reactions: benzylic carbinols bearing in beta-position
Pierre-Emmanuel Broutin1, Françoise Colobert
1Laboratoire de stéréochimie associé au CNRS, UMR 7509 Université Louis Pasteur, ECPM, 25 rue Becquerel, 67087 Strasbourg Cedex 2, France.
Abstract:
Highly atropo-diastereoselective Suzuki coupling between aryl halides bearing stereogenic benzylic carbinols with sulfoxide, thioether, or dimethylamino groups as efficient internal chelating ligands and 2-methoxy-1-naphthylboronic acid were performed with high yields; a palladacycle is proposed as a potential transition state. [reaction: see text]
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