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Migraine: current concepts and emerging therapies.
D K Arulmozhi1, A Veeranjaneyulu, S L Bodhankar
1New Chemical Entity Research, Lupin Research Park, Village Nande, Taluk Mulshi, Pune 411 042, Maharashtra, India. adk_bits@yahoo.com
Vascular Pharmacology
|August 16, 2005
Summary
Migraine is a complex neurovascular disorder impacting millions globally. This review examines current migraine treatments and future therapeutic targets, including calcitonin gene-related peptide, for better patient outcomes.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine is a debilitating neurovascular disorder causing significant disability.
- Current understanding links migraine pathophysiology to vascular, neurological, and neurogenic inflammation theories.
- Existing treatments, including triptans and prophylactic medications, have limitations in efficacy and specificity.
Purpose of the Study:
- To review evidence linking migraine theories to its pathophysiology.
- To critically evaluate current therapeutic targets for acute and prophylactic migraine treatment.
- To explore futuristic approaches for migraine management, focusing on calcitonin gene-related peptide.
Main Methods:
- Literature review of diverse evidence on migraine pathophysiology.
- Critical evaluation of current and emerging migraine therapies.
- Emphasis on calcitonin gene-related peptide as a therapeutic target.
Main Results:
- Migraine is understood as a complex neurovascular disorder.
- Triptans and various prophylactic drugs are used, but effectiveness varies.
- Calcitonin gene-related peptide emerges as a promising target for future treatments.
Conclusions:
- Despite advances, migraine remains underdiagnosed and undertreated.
- A comprehensive understanding of migraine pathophysiology is crucial for developing effective therapies.
- Targeting calcitonin gene-related peptide offers a promising avenue for novel migraine treatments.