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Related Experiment Videos

Antioxidative constituents from Paeonia lactiflora.

Seung Chul Lee1, Yong Soo Kwon, Kyung Hun Son

  • 1College of Pharmacy, Kangwon National University, Chuncheon 200-701, Korea

Archives of Pharmacal Research
|August 24, 2005
PubMed
Summary

Peony root extract (PREs), gallic acid, and methyl gallate show potent antioxidant and antigenotoxic effects. They scavenge free radicals, inhibit lipid peroxidation, and protect against DNA damage without pro-oxidant activity.

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Toxicology

Background:

  • Oxidative stress contributes to various diseases.
  • Natural compounds are explored for antioxidant and protective properties.

Purpose of the Study:

  • To evaluate the antioxidant and antigenotoxic potential of peony root extract (PREs) and its constituents.
  • To assess their protective effects against free radical generation, lipid peroxidation, and DNA damage.

Main Methods:

  • Free radical scavenging activity was measured using 1,1-diphenyl-2-picryl hydrazine (DPPH) assay.
  • Lipid peroxidation was assessed by malondialdehyde (MDA) formation.
  • Hydrogen peroxide-induced DNA damage in NIH/3T3 fibroblasts was evaluated using single cell gel electrophoresis.
  • In vivo antigenotoxicity was assessed by micronucleated reticulocytes (MNRET) formation in mouse peripheral blood.

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Main Results:

  • PREs, gallic acid, and methyl gallate demonstrated significant free radical scavenging and lipid peroxidation inhibitory effects.
  • PREs exhibited no pro-oxidant activity.
  • They effectively inhibited hydrogen peroxide-induced DNA damage in mammalian cells.
  • Oral administration of PREs, gallic acid, and methyl gallate suppressed KBrO3-induced MNRET formation in mice.

Conclusions:

  • Peony root extract, containing gallic acid and methyl gallate, possesses significant antioxidant and antigenotoxic properties.
  • These compounds protect against oxidative stress and DNA damage without adverse pro-oxidant effects.
  • PREs represent a promising natural source for developing antigenotoxic antioxidants.