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Updated: Aug 16, 2026
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
[Expression and significance of EBV LMP2A in nasopharyngeal cancer specimens]
Jiejie Xu1, Kun Yao, Chenjie Yu
1Department of Otolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Objective:
To investigate the expression of Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A) in tumor tissues of nasopharyngeal cancer (NPC) and discuss the possibility (feasibility) that LMP2A was selected (to select
Method:
The expression of EBV LMP2A was detected in the specimens of 40 patients with NPC and 38 cases with nasopharyngeal inflammation by S-P immunohistochemical methods.
Result:
Of the 40 NPC specimens, 36 cases expressed LMP2A. There was no significant relationship between the expression of LMP2A and the histological differentiation of NPC. Thirty-three of the 38 cases with nasopharyngeal inflammation showed negative expression of LMP2A. There was a significant difference of LMP2A expression between NPC and nasopharyngeal inflammation.
Conclusion:
The expression of EBV LMP2A is confirmed in the NPC specimens,and the negative results are seen in the majority of the inflammation cases. There is a possibility of applying LMP2A target antigen to induce specific immunoreaction to kill tumor cells of NPC.