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Updated: Aug 16, 2026
Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
Published on: July 23, 2012
[Role of dendritic cells in the pathogenesis of allergic rhinitis in mouse]
1Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, 430030, China.
Objective:
To investigate the role of dendritic cells in the pathogenesis of acute attack of allergic rhinitis in mouse.
Method:
The adherent precursors of DC were isolated from peripheral blood of allergic rhinitis mouse in acute attack stage and healthy controls. The adherent cells were induced with CpG ODN-1826 to DC in vitro. The expression of the surface molecules CD80, CD86, HLA-DR etc. on the DC was examined by fluorescent activated cell sorter (FACS), so the ability of DCs secrete IL-10, IL-12.
Result:
The results showed that the allergic rhinitis mouse in acute attack stage had remarkably decreased the ability to secret IL-10 compared with normal control subjects (P <0.01), while the ability to secret IL-12 remarkably decreased compared with normal control subjects (P < 0.01); meanwhile, the HLA-DR and co-stimulating factor CD86 expressed by DCs remarkably increased in the allergic rhinitis mouse in acute attack stage compared with the normal control subjects (P < 0.01).
Conclusion:
DC possibly plays a vital role in the immunological mechanism of allergic rhinitis by means of inducing the differentiation of Th1/Th2, that is DC may be the key factor in initiating the airway allergic reaction and the possible mechanism may involve interleukins (especially IL-10 and IL-12, etc.) secreted by DCs.
