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Elastofibroma: clonal fibrous proliferation with predominant CD34-positive cells
Masanori Hisaoka1, Hiroshi Hashimoto
1Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. hisaoka@med.uoeh-u.ac.jp
Virchows Archiv : an International Journal of Pathology
|September 1, 2005
Summary
Elastofibroma, a rare fibrous lesion, may be a clonal proliferation originating from CD34-positive mesenchymal cells. This finding suggests a neoplastic process rather than a reactive one, offering new insights into its etiology.
Area of Science:
- Pathology
- Oncology
- Genetics
Background:
- Elastofibroma is a rare soft tissue lesion of unknown etiology, often considered reactive.
- Recent studies suggest chromosomal abnormalities, hinting at a neoplastic origin.
Purpose of the Study:
- To investigate the cellular composition and clonality of elastofibroma.
- To explore the potential neoplastic nature of elastofibroma.
Main Methods:
- Morphological and immunohistochemical analysis of 14 elastofibroma cases.
- Androgen receptor gene assay to assess clonality in female patients.
Main Results:
- Spindle/stellate cells were fibroblast-like, positive for vimentin, CD34, and lysozyme.
- No myofibroblastic cells were identified.
- Nonrandom X-chromosome inactivation indicated clonality in two informative cases.
Conclusions:
- Elastofibroma contains CD34-positive mesenchymal cells.
- Findings support elastofibroma as a clonal fibrous proliferation, suggesting a neoplastic process.