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Related Experiment Videos

What a rheumatologist needs to know about T cell receptor structure and function.

C G Fathman1

  • 1Department of Medicine, Stanford University School of Medicine, CA 94305-5111.

The Journal of Rheumatology. Supplement
|January 1, 1992
PubMed
Summary

Understanding immune responses and the major histocompatibility complex (MHC) class II pathway is key to developing new treatments for autoimmune diseases like rheumatoid arthritis.

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Area of Science:

  • Immunology and Autoimmune Disease Research

Background:

  • Therapeutic strategies for autoimmune diseases leverage understanding of normal immune responses.
  • Association between autoimmune diseases and major histocompatibility complex (MHC) class II gene products highlights antigen presentation as a therapeutic target.

Purpose of the Study:

  • To review progress in understanding the ternary complex involved in T cell recognition.
  • To identify potential immunotherapeutic interventions for autoimmune diseases, particularly seropositive rheumatoid arthritis.

Main Methods:

  • Review of recent scientific literature on immune response components.
  • Analysis of structure/function relationships of T cell receptors.

Main Results:

  • Progress has been made in understanding the components of the ternary complex (antigen, MHC class II, T cell receptor).

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  • The interaction between antigen-presenting cells, MHC class II, and CD4(+) T cells is a critical target for intervention.

    • Conclusions:

    • Understanding the ternary complex provides insights into autoimmune disease pathogenesis.
    • Novel immunotherapeutic strategies for seropositive rheumatoid arthritis may arise from targeting T cell receptor-antigen interactions.