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Study protocol: the DOse REsponse Multicentre International collaborative initiative (DO-RE-MI).

Detlef Kindgen-Milles1, Didier Journois, Roberto Fumagalli

  • 1Anesthesiology Clinic, University of Düsseldorf, Germany. Kindgen-Milles@med.uni-duesseldorf.de

Critical Care (London, England)
|September 3, 2005
PubMed
Summary

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This summary is machine-generated.

This study investigates renal replacement therapy practices in intensive care units (ICUs). It aims to define current approaches and their impact on patient outcomes, including mortality and length of stay.

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Clinical Research

Background:

  • Current practices for renal replacement therapy (RRT) in intensive care units (ICUs) are not well-defined.
  • The DOse REsponse Multicentre International collaborative initiative (DO-RE-MI) aims to clarify RRT selection and performance.
  • This document outlines the study protocol for the DO-RE-MI initiative.

Purpose of the Study:

  • To investigate the delivered dose of dialysis in ICUs.
  • To compare dialysis dose with patient outcomes such as mortality and length of stay.
  • To assess the hemodynamic response to RRT, measured by changes in noradrenaline requirements.

Main Methods:

  • An observational, multicentre study conducted in ICUs.
  • Recruitment of at least 162 patients.

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  • Data collection via online electronic case report forms, ensuring data anonymization.

    • Main Results:

    • The study is designed to compare the delivered dose of dialysis with key clinical outcomes.
    • It will analyze the relationship between RRT and mortality, ICU length of stay, and mechanical ventilation duration.
    • Secondary analysis will focus on hemodynamic responses to RRT.

    Conclusions:

    • The study is expected to provide valuable insights into current RRT practices in ICUs.
    • It will facilitate a centre-based data collection for monitoring extracorporeal support.
    • Findings will contribute to a better understanding of RRT's role in critical care settings.