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Related Experiment Videos

Pernio in pediatrics.

Tamara D Simon1, Jennifer B Soep, J Roger Hollister

  • 1Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA. tamara.simon@uchsc.edu

Pediatrics
|September 6, 2005
PubMed
Summary
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Pernio (chilblains) can affect adolescents, presenting as painful skin lesions after cold exposure. Early recognition and prevention are key for excellent outcomes, with nifedipine showing effectiveness.

Area of Science:

  • Dermatology
  • Rheumatology
  • Pediatrics

Background:

  • Pernio (chilblains) is an inflammatory skin condition caused by abnormal response to cold.
  • It commonly affects young women and can occur in children and older adults.
  • Lesions typically appear in fall/winter and resolve in spring/summer.

Purpose of the Study:

  • To report on five cases of pernio in adolescent females seen at a pediatric tertiary care center.
  • To discuss the presentation, differential diagnosis, and management of pernio.
  • To explore potential reasons for an observed increase in cases.

Main Methods:

  • Retrospective case series of five adolescent female patients.
  • Clinical evaluation including physical examination and laboratory tests.

Related Experiment Videos

  • Review of pernio literature regarding predisposing factors and treatment.

    • Main Results:

    • All five patients were thin (BMI <25th percentile) with affected toes or fingers.
    • Laboratory results were unremarkable, including negative antinuclear antibody tests.
    • Symptomatic treatment was recommended; nifedipine showed effectiveness in reducing pain and healing.

    Conclusions:

    • Pernio can affect adolescents, particularly those who are thin and exposed to cold.
    • Differential diagnosis includes Raynaud's phenomenon and frostbite.
    • Prevention and symptomatic treatment are crucial; nifedipine may be beneficial.