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[AP-2 expression and significance in the lung cancer tissues]
Rui Zhou1, Ping Chen, Guang-Sen Zhang
1Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China. zhourui64@yahoo.com
Objective:
To determine the active protein-2 (AP-2) expression in non-small cell lung cancer (NSCLC) and the relationship between the expression and tumor biological characteristics.
Methods:
Fifty NSCLC tissues and 15 normal lung tissues were used to detect the expression of AP-2 transcription factor with the immunohistochemical method.
Results:
The positive rate of AP-2 expression was zero in the normal lung tissues, but 32% in the NSCLC tissues. The AP-2 expression in the NSCLC tissues was significantly elevated (P < 0.05). The postive rate of AP-2 expression was significantly higher in the NSCLC tissues of pathological grade III (57.89%) than in those of grade I - II (16.13%) (P < 0.05), and higher in patients of clinical stage III - IV (44. 83%) than in those of stage I - II (14.29%) (P <0.01), and in the NSCLC patients with lymph node metastasis (40.54%) than in those without (7.7%) (P < 0.05).
Conclusion:
The up-regulation of AP-2 expression in the NSCLC tissues suggests that AP-2 may be involved in the NSCLC carcinogenesis. AP-2 may play an important role in the genesis and development of NSCLC.