Functional role of the neurospecific S-100 protein in the processes of memory

The change in the content of S-100 protein in the brain in the presence of learning and an amnestic influence (administration of an M-cholinolytic), taking interhemispheric asymmetry into account, was studied in experiments on white rats. The action of S-100 protein and of an antiserum to this protein on the learned behavior of the rats were also investigated. It was established that the level of S-100 protein increases in the left and right hemispheres in the process of the development of an alimentary conditioned reflex. The disruption induced by the cholinolytic of the processes of the development of conditioned reflexes is accompanied by a decrease in the content of S-100 protein in the brain. Intracisternal administration of an M-cholinolytic and an antiserum to S-100 protein mutually potentiates their amnestic effect.