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Congenital microcoria associated with late-onset developmental glaucoma
Akihiko Tawara1, Ken Itou, Toshiaki Kubota
1Department of Ophthalmology, School of Medicine, University of Occupational and Environmental Health, Japan. Tawara-a@med.uoeh-u.ac.jp
Journal of Glaucoma
|September 9, 2005
Summary
Developmental glaucoma, characterized by iridocorneal angle maldevelopment, is linked to congenital microcoria. This study observed late-onset glaucoma in families with congenital microcoria.
Area of Science:
- Ophthalmology
- Genetics
- Developmental Biology
Background:
- Developmental glaucoma, defined by goniodysgenesis from fetal iridocorneal angle maldevelopment, is investigated.
- The study uses the term developmental glaucoma instead of goniodysgenetic glaucoma.
- Congenital microcoria is explored as a potential associated condition.
Observation:
- A family with autosomal dominant congenital microcoria and goniodysgenesis was studied over 25 years.
- Three subjects across three generations were followed.
- Late-onset goniodysgenetic glaucoma was observed in individuals with congenital microcoria.
Findings:
- Congenital microcoria was frequently associated with late-onset goniodysgenetic glaucoma.
- Histological analysis revealed thickened juxtacanalicular connective tissue and extracellular matrix accumulation in iridocorneal angle tissues.
- Two subjects with congenital microcoria and goniodysgenesis developed bilateral late-onset glaucoma, requiring trabeculectomy.
Implications:
- Congenital microcoria may serve as an indicator for the potential development of late-onset glaucoma.
- Understanding this association can aid in early diagnosis and management of glaucoma in affected families.
- Further research into the genetic and developmental mechanisms linking microcoria and glaucoma is warranted.