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[Follicular bronchiolitis: a pediatric case report].

A Labbé1, P Déchelotte, I Creveaux

  • 1Service de Pédiatrie A, Hôtel-Dieu, Clermont-Ferrand.

Revue Des Maladies Respiratoires
|January 1, 1992
PubMed
Summary

This case report details an infant with persistent bronchiolitis and respiratory failure, unresponsive to standard treatments. Diagnosis required lung biopsy, revealing follicular bronchitis and suggesting genetic testing for delta F 508 mutations in similar cases.

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Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Case Study

Background:

  • Bronchiolitis is a common respiratory infection in infants.
  • Persistent or severe cases may indicate underlying conditions.
  • Standard treatments often include bronchodilators and corticosteroids.

Observation:

  • A six-month-old infant presented with insidious bronchiolitis, progressing to respiratory failure and failure to thrive.
  • Conventional therapies, including corticosteroids and bronchodilators, were ineffective.
  • Assisted ventilation was required for three weeks due to persistent bronchial obstruction.

Findings:

  • Open lung biopsy revealed characteristic lesions of bronchiolitis and follicular bronchitis.
  • No other parenchymal lung disease was identified.

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  • The patient showed clinical and radiological improvement with antibiotics and physiotherapy.

    • Implications:

    • Follicular bronchitis in infants warrants thorough investigation for underlying causes.
    • The possibility of heterozygous delta F 508 mutation should be considered in unexplained obstructive airway disease.
    • Genetic screening for delta F 508 may aid in diagnosing and managing chronic respiratory issues in infants.