Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Podocyte-derived endothelin-1 and endothelial cell endothelin A receptors are essential for glomerular injury in mouse models of focal segmental glomerulosclerosis.

Kidney international·2026

Same author

Liquid Biopsy-Multiomics Link Adhesion Pathway Dysregulation to Kidney Injury Severity.

Kidney international reports·2025

Same author

Ultrasound Imaging and Machine Learning for Nondestructive Sensing in Bioreactors.

ACS omega·2025

Same author

Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data".

Molecular & cellular proteomics : MCP·2025

Same author

Biocompatibility of decellularized spinach leaves.

npj biomedical innovations·2025

Same author

Large iliofemoral aneurysm harboring intramural fibrin-associated B-cell lymphoma.

Journal of vascular surgery cases and innovative techniques·2025

Same journal

Eugene Braunwald, MD, 1929-2026.

Circulation·2026

Same journal

AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026).

Circulation·2026

Same journal

Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry.

Circulation·2026

Same journal

Heart Failure Occurring in the Perinatal Period: A Scientific Statement From the American Heart Association.

Circulation·2026

Same journal

Correction to: 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Circulation·2026

Same journal

Correction to: The Natural History of Massive Left Ventricular Hypertrophy in Pediatric Hypertrophic Cardiomyopathy: A Multiregistry Analysis.

Circulation·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 4, 2026

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Published on: December 20, 2010

Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function.

Paul V Kochupura¹, Evren U Azeloglu, Damon J Kelly

¹Department of Surgery, Stony Brook University, Stony Brook, New York, USA.

|September 15, 2005

Summary

This summary is machine-generated.

Extracellular matrix (ECM) myocardial patches improved regional heart function and showed cardiomyocyte regeneration, unlike Dacron patches. This tissue-engineered scaffold offers superior mechanical benefits for myocardial repair.

More Related Videos

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Published on: September 26, 2020

Related Experiment Videos

Last Updated: May 4, 2026

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Published on: December 20, 2010

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Published on: September 26, 2020

Area of Science:

Biomaterials Science
Cardiovascular Research
Tissue Engineering

Background:

Extracellular matrix (ECM) serves as a tissue-engineered scaffold, promoting cardiomyocyte regeneration post-myocardial implantation.
Dacron is a conventional material for myocardial patches in surgical restoration.
ECM-derived patches may offer mechanical advantages over Dacron.

Purpose of the Study:

To compare the mechanical and functional benefits of ECM-derived myocardial patches versus Dacron patches in a canine model.
To evaluate the regenerative potential of ECM patches in cardiac tissue repair.

Main Methods:

Canine model with right ventricle defects repaired with ECM or Dacron patches.
Assessment of global and regional systolic and diastolic function at 8 weeks.
Histological evaluation including immunohistochemistry to identify cardiomyocyte infiltration.

Main Results:

Global systolic and diastolic functions were comparable between ECM and Dacron groups.
ECM patches demonstrated significantly improved regional systolic function (systolic area contraction) compared to Dacron.
ECM patches showed enhanced regional diastolic function (recoil rate) and cardiomyocyte presence, which was absent in Dacron implants.

Conclusions:

ECM-derived myocardial patches provide regional mechanical benefits at 8 weeks post-implantation, attributed to cardiomyocyte repopulation.
These findings highlight the superior efficacy of ECM patches over traditional Dacron patches for myocardial repair.