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Updated: Aug 15, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Response of serum C-reactive protein to percutaneous coronary intervention has prognostic value

Nawsad Saleh1, Bertil Svane, Lars-Olof Hansson

  • 1Department of Cardiology, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden. nawzad.saleh@karolinska.se

Clinical Chemistry
|September 17, 2005
PubMed

Insights

Elevated C-reactive protein (CRP) after percutaneous coronary intervention (PCI) predicts long-term adverse outcomes, including death or myocardial infarction. This inflammatory marker offers valuable risk stratification post-PCI, independent of procedural injury.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • Limited data exists on C-reactive protein (CRP) and long-term prognosis after percutaneous coronary intervention (PCI).
  • Percutaneous coronary intervention is known to elicit an inflammatory response.
  • The prognostic significance of the CRP response to PCI requires further investigation.

Purpose of the Study:

  • To test the hypothesis that the CRP response following PCI has prognostic value.
  • To evaluate the association between CRP levels and long-term outcomes after PCI.
  • To determine if CRP serves as an independent predictor of adverse events post-PCI.

Main Methods:

  • Investigated 891 patients undergoing PCI for stable or unstable angina.
  • Measured serum CRP and cardiac troponin T before and after PCI.
  • Followed patients for a mean of 2.6 years, with endpoints of death or nonfatal myocardial infarction.

Main Results:

  • A more than 2-fold increase in CRP was observed post-PCI.
  • Patients in the highest tertile of CRP response had an increased risk of death or nonfatal myocardial infarction.
  • 21% of patients experienced myocardial infarction during the procedure.

Conclusions:

  • Increased serum CRP post-PCI is an independent predictor of death or nonfatal myocardial infarction.
  • The prognostic value of CRP is independent of myocardial injury sustained during the procedure.
  • CRP measurements may enhance risk stratification for patients undergoing PCI.
Abstract

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