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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Mechanisms regulating lymphocytic infiltration of the thyroid in murine models of thyroiditis
Sergio A Lira1, Andrea P Martin, Tatjana Marinkovic
1Immunobiology Center, Mount Sinai School of Medicine, Box 1630, New York, NY 10029-6574, USA. sergio.lira@mssm.edu
Critical Reviews in Immunology
|September 20, 2005
Abstract:
The autoimmune diseases of the thyroid are the most prevalent autoimmune diseases in man. In these diseases, the thyroid is invariably infiltrated by lymphocytes, which play a major role in pathogenesis. In this review, we discuss the mechanisms associated with lymphocytic infiltration of the thyroid, examining different models of thyroid autoimmune disease in mice.

