Related Experiment Videos
Serum tumor necrosis factor-alpha in pre eclampsia.
Sazina Muzammil1, Usha Singhal, Rajiv Gulati
1Department of Physiology, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh 202 001.
Indian Journal of Physiology and Pharmacology
|September 21, 2005
Summary
Serum tumor necrosis factor-alpha (TNF-alpha) levels are significantly elevated in preeclampsia. This study found higher TNF-alpha in preeclamptic women compared to normal pregnancies, independent of maternal age or blood pressure.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Pathophysiology
Background:
- Cytokines play a crucial role in the development of preeclampsia.
- Tumor necrosis factor-alpha (TNF-alpha) is implicated in inflammatory processes during pregnancy.
Purpose of the Study:
- To investigate serum TNF-alpha levels in preeclamptic versus normal pregnancies.
- To assess the correlation between TNF-alpha levels and maternal age, parity, and mean arterial pressure.
Main Methods:
- Serum samples were collected from 10 normal and 30 preeclamptic pregnant women.
- Tumor necrosis factor-alpha (TNF-alpha) was quantified using the sandwich ELISA technique.
Main Results:
- Serum TNF-alpha levels were significantly higher in preeclamptic pregnancies (67.66 +/- 61.83 pg/ml) compared to normal pregnancies (9.3 +/- 0.56 pg/ml) (P < 0.001).
- No significant associations were found between serum TNF-alpha levels and maternal age, parity, or mean arterial pressure in either group.
Conclusions:
- Elevated serum TNF-alpha is a significant finding in preeclampsia.
- TNF-alpha levels in preeclampsia are not influenced by maternal age, parity, or mean arterial pressure.