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Chemokines: their role in rheumatoid arthritis
Clarissa E Vergunst1, Paul P Tak
1Division of Clinical Immunology and Rheumatology, F4-218, Academic Medical Center/University of Amsterdam, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands. c.e.vergunst@amc.nl
Abstract:
Chemokines are small proteins that can act on cells that express matching receptors. They are best known for their role in migration of cells, especially immune cells. Chemokine/chemokine-receptor pairs are often functionally categorized into three groups: inflammatory, homeostatic, and angiogenic/angiostatic, although functions sometimes overlap. Interfering with the interaction between chemokines and their receptors is currently under investigation as a therapeutic strategy in rheumatoid arthritis.
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