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A strategy for integrative computational physiology

Peter Hunter1, Poul Nielsen

  • 1Bioengineering Institute, University of Auckland, Auckland, New Zealand. p.hunter@auckland.ac.nz

Physiology (Bethesda, Md.)
|September 22, 2005
PubMed

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Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...