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A strategy for integrative computational physiology.

Peter Hunter1, Poul Nielsen

  • 1Bioengineering Institute, University of Auckland, Auckland, New Zealand. p.hunter@auckland.ac.nz

Physiology (Bethesda, Md.)
|September 22, 2005
PubMed
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Understanding organ function requires integrating molecular, cellular, and tissue-level processes. This study introduces a quantitative modeling framework for multiscale physiological research, as part of the International Union of Physiological Sciences Physiome Project.

Area of Science:

  • Physiology
  • Computational Biology
  • Systems Biology

Background:

  • Organ function, such as the heart beat, is complex.
  • Understanding organ function necessitates integrating knowledge across multiple biological scales.

Purpose of the Study:

  • To describe a quantitative modeling framework.
  • To address multiscale issues in physiological research.
  • To present the framework under the International Union of Physiological Sciences Physiome Project.

Main Methods:

  • Development of a quantitative modeling framework.
  • Integration of molecular, cellular, and tissue-level data.
  • Focus on structure-function relationships.

Main Results:

Related Experiment Videos

  • A framework for multiscale physiological modeling is established.
  • The framework enables understanding of organ function through integrated processes.

Conclusions:

  • A quantitative approach is essential for understanding complex organ function.
  • The described framework supports multiscale physiological research within the Physiome Project.