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Noninvasive assessment of intracranial pressure waveforms by using pulsed phase lock loop technology. Technical note
Toshiaki Ueno1, Brandon R Macias, William T Yost
1Department of Orthopaedic Surgery, University of California San Diego, California, USA. tueno@med.teikyo-u.ac.jp
Journal of Neurosurgery
|September 24, 2005
Summary
A new noninvasive ultrasonic device accurately monitors intracranial pressure (ICP) waveforms using pulsed phase lock loop (PPLL) technology. This innovation offers a promising alternative to invasive methods for neurological patients.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Medical Devices
Background:
- Elevated intracranial pressure (ICP) significantly contributes to morbidity and mortality in neurological disorders.
- Current ICP monitoring methods are invasive, limiting their use to severe cases.
Purpose of the Study:
- To develop and validate a noninvasive ultrasonic device for monitoring ICP waveforms.
- To correlate noninvasive ICP waveforms with invasive measurements.
Main Methods:
- Development of an ultrasonic device utilizing pulsed phase lock loop (PPLL) technique to record skull movement.
- Correlation analysis between PPLL-derived waveforms and invasively measured ICP waveforms in 13 patients.
- Linear regression, coherence function, and harmonic distortion ratio analyses were employed.
Main Results:
- High correlation (r2 = 0.88) found between PPLL and invasive ICP waveforms in the time domain.
- Medium to high correlations (r2 = 0.50-0.90) observed at harmonic wave components.
- Significant correlation (r2 = 0.680, p < 0.01) in harmonic distortion ratio between PPLL and invasive ICP.
Conclusions:
- PPLL technology provides a viable noninvasive method for evaluating ICP dynamics.
- This noninvasive approach has potential for broader clinical application in managing neurological conditions.
- The study demonstrates the efficacy of PPLL for accurate, noninvasive ICP waveform monitoring.