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Structure and antiinflammatory activity relationships of wogonin derivatives
Jinhee Jang1, Kwan-Seog Sin, Hyun Pyo Kim
1College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea.
Abstract:
A number of wogonin derivatives have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE2 production. Wogonin derivatives modified at the B ring of wogonin were obtained from 2,4-Dihydroxy-3,6-dimethoxyacetophenone (1) via several steps. Most wogonin derivatives exhibited much reduced inhibitory activities against COX-2 catalyzed PGE2 production compared to that of wogonin. Alkylation of 5,7-phenol groups and substitution at the B ring of wogonin generally caused reduction of inhibitory activity.
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