Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a Core Outcome Domain Set for Facial Aging.

JAMA dermatology·2026
Same author

Intradermal tranexamic acid and melasma: a systematic review and level of evidence.

Italian journal of dermatology and venereology·2026
Same author

Epigenetic Clocks in Skin Aging: From Exposome Drivers to Biomarkers and Therapeutic Interventions.

Clinical, cosmetic and investigational dermatology·2026
Same author

Skin & Digital: The 2024 Startups.

JID innovations : skin science from molecules to population health·2025
Same author

Correlating Optical Coherence Tomography and Other Noninvasive Imaging Features With Atrophic and Hypertrophic Skin Photoaging.

International journal of dermatology·2025
Same author

Biostimulatory Fillers to Treat Post-liposuction Skin Irregularities.

The Journal of clinical and aesthetic dermatology·2025

Related Experiment Video

Updated: Jun 16, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Psoriasis: a fresh look.

Ibrahim Galadari1, Mohamed Omar Sharif, Hassan Galadari

  • 1Department of Dermatology, Al Ain Hospital, Al Ain, United Arab Emirates. galadari@email.com

Clinics in Dermatology
|September 24, 2005
PubMed
Summary

Psoriasis involves scaly skin lesions driven by keratinocyte hyperplasia. Activated T lymphocytes are key drivers, leading to new biologic therapies targeting T-cell and cytokine pathways.

Area of Science:

  • Immunodermatology
  • Molecular biology
  • Cellular immunology

Background:

  • Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperplasia and scaly lesions.
  • Activated T lymphocytes are identified as the primary factor stimulating keratinocytes in psoriatic lesions.
  • Understanding psoriasis pathogenesis is crucial for developing targeted therapeutic interventions.

Purpose of the Study:

  • To review the role of T lymphocytes in psoriasis pathogenesis.
  • To discuss the development and potential of biologic response modifiers in psoriasis treatment.
  • To highlight advances in understanding disease mechanisms for novel therapy development.

Main Methods:

  • Review of existing literature on psoriasis immunology and pathogenesis.

More Related Videos

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
06:34

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

Published on: August 8, 2025

Related Experiment Videos

Last Updated: Jun 16, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
06:34

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

Published on: August 8, 2025

  • Analysis of T-cell activation pathways and cytokine signaling in psoriatic skin.
  • Examination of biotechnological approaches for developing targeted therapies.

    • Main Results:

    • Confirmation of activated T lymphocytes as central mediators in psoriasis.
    • Identification of specific T-cell subsets and cytokines involved in disease progression.
    • Emergence of biologic response modifiers as promising targeted immunosuppressive agents.

    Conclusions:

    • Targeting T-cell activation and cytokine pathways offers a promising therapeutic strategy for psoriasis.
    • Biologic response modifiers represent a significant advancement in managing psoriasis by modulating immune responses.
    • Continued research into psoriasis pathogenesis will drive the development of more effective and specific treatments.