Characteristics of dorsal and ventral striatal kindling in rats

We examined the characteristics of kindling of seizures with stimulation of the dorsal or ventral striatum in rats. Different groups of rats carried electrodes directed towards the nucleus accumbens or the head, middle, or tail of the caudate. Thresholds for afterdischarge (AD) were high at all sites, and stimulation often produced forced motor responses (motor responses that occurred during the stimulation and were not a consequence of kindling). Kindling at sites in the accumbens proceeded more slowly than at the sites in the caudate, which did not differ among themselves. The duration of accumbens seizures increased dramatically over the course of kindling, whereas the duration of caudate seizures remained relatively short and invariant. Although the kindled seizures resembled seizures kindled from limbic sites, they also contained aspects of seizures triggered from stimulation of the anterior neocortex. We conclude that striatal kindling comprises elements of both limbic and neocortical kindling.