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Updated: Aug 15, 2026
08:39
Electroporation of Functional Bacterial Effectors into Mammalian Cells
Published on: January 19, 2015
The functional interface between Salmonella and its host cell: opportunities for therapeutic intervention
Jayesh C Patel1, Olivia W Rossanese, Jorge E Galán
1Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA. jorge.galan@yale.edu
Trends in Pharmacological Sciences
|September 27, 2005
Summary
Salmonella pathogenesis involves type III secretion systems delivering effector proteins into host cells. Understanding these molecular interactions can lead to new therapeutics targeting Salmonella infection.
Area of Science:
- Microbiology
- Pathogen-host interactions
- Molecular biology
Background:
- Salmonella is a facultative intracellular pathogen causing diseases like enteritis and typhoid fever.
- It utilizes two type III secretion systems (T3SS) to inject effector proteins into host cells, crucial for virulence.
Purpose of the Study:
- To elucidate the molecular mechanisms underlying Salmonella pathogenesis.
- To characterize virulence proteins and their host-cell targets at an atomic level.
Main Methods:
- Recent characterization of Salmonella virulence proteins.
- Analysis of host-cell targets of these proteins.
Main Results:
- Uncovering detailed molecular mechanisms of Salmonella pathogenesis.
- Revealing the atomic-level interface between Salmonella and host cells.
Conclusions:
- Detailed understanding of pathogen-host molecular interactions.
- Potential for designing novel therapeutics to disrupt Salmonella infection and disease processes at the molecular level.
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