Related Experiment Video
Updated: Aug 15, 2026

07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Vitamin K deficiency mimicking child abuse
Tonia J Brousseau1, Niranjan Kissoon, Bruce McIntosh
1Division of Pediatric Emergency Medicine, University of Florida Health Sciences Center, Jacksonville, Florida, USA.
The Journal of Emergency Medicine
|September 27, 2005
Summary
Infants born outside the hospital may lack vitamin K prophylaxis, risking serious bleeding. This case highlights vitamin K deficiency as a crucial differential diagnosis in infants presenting with intracranial hemorrhage and suspected abuse.
Area of Science:
- Pediatrics
- Neonatology
- Hematology
Background:
- Infants require supplemental vitamin K for proper hemostasis.
- Infants born outside a clinical setting may not receive prophylactic vitamin K.
- Vitamin K deficiency can lead to severe bleeding complications in newborns.
Observation:
- A home-born infant presented with intracranial bleeding.
- Clinical signs and symptoms suggested potential child abuse.
- The infant's presentation mimicked non-accidental trauma.
Findings:
- Further investigations confirmed Vitamin K deficiency as the cause of bleeding.
- The infant's intracranial hemorrhage was directly linked to vitamin K deficiency.
- Diagnosis was established despite initial suspicion of child abuse.
Implications:
- Clinicians must consider Vitamin K deficiency in infants with intracranial bleeding, especially those born outside hospitals.
- Vitamin K deficiency should be a key differential diagnosis alongside child abuse in infants with unexplained bleeding.
- Timely diagnosis and treatment of Vitamin K deficiency are critical to prevent severe outcomes.
Related Concept Videos
Vitamins
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Role of Vitamins in Maintaining Bone Health
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Skin in Vitamin D Synthesis
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Overview of Protein Metabolism
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...