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Published on: May 10, 2017
[Expression of B cell-specific activator protein in lymphomas]
Dan Li1, Gan-di Li, Wei-ping Liu
1Department of Pathology, Huaxi Hospital, Sichuan University, Chengdu 610041, China.
Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|September 28, 2005
Summary
B cell-specific activator protein (BSAP)/Pax-5 is a novel nuclear marker for B-cell lymphomas. While CD20 is more sensitive, BSAP aids in diagnosing B-cell lymphomas in pathology practice.
Area of Science:
- Hematology
- Oncology
- Immunohistochemistry
Background:
- B-cell lymphomas are malignancies of B lymphocytes.
- Accurate diagnosis relies on identifying specific cellular markers.
- B cell-specific activator protein (BSAP), also known as Pax-5, is a transcription factor crucial for B-cell development.
Purpose of the Study:
- To investigate the expression patterns of BSAP/Pax-5 in various types of lymphomas.
- To evaluate the utility of BSAP/Pax-5 as a diagnostic marker in B-cell lymphomas.
Main Methods:
- Immunohistochemical analysis was performed on 102 cases of diffuse large B-cell lymphoma (DLBCL).
- Additional cases included follicular lymphoma (FL), extranodal marginal zone B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), anaplastic large cell lymphoma (ALCL), and plasmacytoma.
- Expression of BSAP/Pax-5 and CD20 was assessed in all studied lymphoma types.
Main Results:
- All DLBCL cases expressed CD20, with 100 out of 102 also expressing BSAP/Pax-5.
- Follicular lymphoma, extranodal marginal zone B-cell lymphoma, and NLPHL cases showed co-expression of BSAP/Pax-5 and CD20.
- Anaplastic large cell lymphoma and plasmacytoma cases lacked expression of both BSAP/Pax-5 and CD20.
- High concordance was observed between CD20 and BSAP/Pax-5 expression, with no significant difference in staining intensity.
Conclusions:
- BSAP/Pax-5 is a reliable nuclear marker for B-cell lymphomas.
- Although less sensitive than CD20, BSAP/Pax-5 demonstrates diagnostic value in routine surgical pathology.
- The consistent expression in B-cell lymphomas supports its role in differential diagnosis.
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