Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evaluation of the structure-function relationship in glaucoma.

Stuart K Gardiner1, Chris A Johnson, George A Cioffi

  • 1Discoveries In Sight, Devers Eye Institute, Portland, OR 97208, USA. sgardiner@discoveriesinsight.org

Investigative Ophthalmology & Visual Science
|September 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraocular Pressure Measurement Variability in the Ocular Hypertension Treatment Study.

Ophthalmology. Glaucoma·2026
Same author

Ophthalmology Resident Clinics-A Road Paved With Good Intentions.

JAMA ophthalmology·2026
Same author

Location of visual field defects and their impact on vision-related quality of life in glaucoma: A systematic review.

Optometry and vision science : official publication of the American Academy of Optometry·2026
Same author

Extravascular Motion Signal Detected by OCT Angiography Indicates Altered Vascular-Tissue Biomechanical Interactions in Glaucoma.

Investigative ophthalmology & visual science·2026
Same author

Glaucomatous Remodeling of the Lamina Cribrosa: Association With Visual Field Progression.

Investigative ophthalmology & visual science·2026
Same author

Characterization of Temporal Delay and Modeling of Intraocular Pressure and Visual Field Progression in the African Descent and Glaucoma Evaluation Study.

Ophthalmology. Glaucoma·2026
Same journal

Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus.

Investigative ophthalmology & visual science·2026
Same journal

Psychometric Performance of Children With Amblyopia During a Tablet-Based Adaptive Visual Acuity Assessment.

Investigative ophthalmology & visual science·2026
Same journal

The Molecular Basis of Ocular Aging: Mechanisms, Pathologies, and Emerging Therapeutics.

Investigative ophthalmology & visual science·2026
Same journal

Sensory Eye Dominance Remains Stable Across Binocular Combination and Rivalry in Normal and Anisometropic Amblyopic Vision.

Investigative ophthalmology & visual science·2026
Same journal

Exosome-Associated Gene Network and the Role of SPP1 in Herpes Stromal Keratitis and the Therapeutic Modulation by Ursolic Acid.

Investigative ophthalmology & visual science·2026
Same journal

Nonlinear Associations of Estimated Glucose Disposal Rate With Incident Age-Related Eye Diseases: Implications for Metabolic Risk Stratification.

Investigative ophthalmology & visual science·2026
See all related articles

This study maps optic nerve head (ONH) structure to visual field function, revealing correlations between ONH sectors and visual field locations to better understand glaucoma progression.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Glaucoma diagnosis relies on structural and functional tests, but the precise spatial link between optic nerve head (ONH) structure and visual field function remains unclear.
  • Understanding this structure-function relationship is crucial for diagnosing and managing glaucoma, particularly localized visual field defects.

Purpose of the Study:

  • To create a topographical map correlating specific sectors of the optic nerve head (ONH) with corresponding locations in the visual field.
  • To elucidate the spatial relationship between ONH structure and visual field sensitivity using patient data.

Main Methods:

  • Utilized data from 109 healthy and 166 glaucoma subjects, employing a retina tomograph for ONH imaging and standard automated perimetry (SAP) for visual field testing.

Related Experiment Videos

  • Normalized optic nerve head (ONH) rim areas from 36 sectors and correlated these with visual field thresholds from SAP.
  • Generated a correlation map indicating the strength of association between ONH sectors and visual field locations.

    • Main Results:

    • A significant correlation (up to 0.520) was found between normalized ONH sector rim areas and visual field sensitivity at specific locations.
    • Over half of the tested visual field locations (27/52) showed a correlation above 0.2 with at least one ONH sector.
    • A consistent pattern emerged: superior hemifield locations correlated with inferior temporal ONH sectors, and inferior hemifield locations correlated with superior temporal ONH sectors.

    Conclusions:

    • A novel topographical map effectively relates specific optic nerve head (ONH) regions to standard automated perimetry (SAP) test locations.
    • This structure-function map offers a valuable tool for understanding glaucomatous visual field loss, especially in cases with localized defects.