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The depth of molecular recognition: voltage-sensitive blockage of synthetic multifunctional pores with refined
Yoann Baudry1, Dario Pasini, Masamichi Nishihara
1Department of Organic Chemistry, University of Geneva, Switzerland.
Chemical Communications (Cambridge, England)
|September 30, 2005
Abstract:
Voltage-sensitive blockage by ADP, ATP and phytate (IP6) demonstrates that active-site contraction toward the middle of newly synthesized rigid-rod beta-barrels provides a general strategy to rationally create and modulate the voltage sensitivity (and to increase the efficiency) of molecular recognition by synthetic multifunctional pores.
