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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
Published on: July 3, 2013
[Calcium antagonists and ischemic heart disease]
Hidehiro Matsuoka1, Tsutomu Imaizumi
1Department of Internal Medicine III, Kurume University School of Medicine.
Insights
Long-acting calcium antagonists are effective and well-tolerated blood pressure medications. They may be crucial for managing ischemic heart disease due to their anti-atherogenic effects and proven clinical benefits.
Area of Science:
- Pharmacology
- Cardiology
- Vascular Biology
Context:
- Long-acting calcium antagonists exhibit diverse anti-atherogenic properties.
- These agents are recognized for their efficacy and tolerability in lowering blood pressure.
Purpose:
- To review the role of long-acting calcium antagonists in managing ischemic heart disease.
- To highlight their therapeutic potential based on clinical evidence.
Summary:
- Clinical trials demonstrate improved outcomes in coronary artery disease patients treated with these agents.
- Their anti-atherogenic effects contribute to their cardiovascular benefits.
Impact:
- Long-acting calcium antagonists show promise as a central therapeutic strategy for ischemic heart disease.
- Evidence supports their use in improving cardiovascular health and patient outcomes.
Abstract:
Long-acting calcium antagonists, which have a wide-variety of anti-atherogenic properties, are well-tolerable and highly efficacious blood pressure lowering agents. Since a number of large prospective trials demonstrated the improvement of clinical outcomes in patients with coronary artery diseases, long-acting calcium antagonists may play a central role in the therapeutic strategy for ischemic heart disease.
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