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Human cytomegalovirus, endothelial function and atherosclerosis.

Cairistine Grahame-Clarke¹

¹Department of Cardiology, Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UZ, UK. CAIRISTINE.GRAHAME-CLARKE@nnuh.nhs.uk

Herpes : the Journal of the IHMF

|October 8, 2005

Summary

Human cytomegalovirus (HCMV) serology is associated with endothelial dysfunction. Further research is needed to determine if HCMV causes atherosclerosis in the general population.

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Area of Science:

Virology
Immunology
Cardiovascular Science

Background:

Human cytomegalovirus (HCMV) serology correlates with endothelial dysfunction.
HCMV is implicated in transplant arterial disease and preeclampsia.
The role of HCMV in general atherosclerosis is not well-established.

Purpose of the Study:

To investigate the potential causal link between HCMV and atherosclerosis in immunocompetent individuals.

Main Methods:

This study reviews existing evidence and highlights the need for further investigation.
No new experimental data was generated.

Main Results:

Existing serological data suggests a link between HCMV and endothelial dysfunction.
HCMV's role in transplant arterial disease and preeclampsia is supported by substantial evidence.

Conclusions:

The clinical significance of HCMV as a cause of atherosclerosis in the general population requires further research.

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