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Effect of object transport on grasp coordination in multiple system atrophy
Lisa M Muratori1, Geraldine Dapul, Matthew N Bartels
1Department of Biobehavioral Science, Teachers College, Columbia University, New York, NY 10027, USA.
Summary
Patients with multiple-system atrophy parkinsonian (MSA-P) exhibit significant temporal and force coordination deficits during object manipulation tasks, impacting movement speed and precision.
Area of Science:
- Neuroscience
- Motor Control
- Neurology
Background:
- Multiple-system atrophy parkinsonian (MSA-P) is a neurodegenerative disorder affecting motor function.
- Understanding the specific motor deficits in MSA-P is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the impact of MSA-P on the sensorimotor control of object grasp, transport, and release.
- To quantify temporal and force coordination abnormalities in individuals with MSA-P.
Main Methods:
- Twelve patients with MSA-P and ten age-matched controls performed an object manipulation task with varying weights (200, 400, 800 gm).
- Precision grip forces (grip and load) and object position were recorded during self-paced movements.
Main Results:
- Subjects with MSA-P showed prolonged movement times and significant temporal delays throughout the task, particularly during transport and object release.
- Despite appropriate anticipatory force scaling for object weight, MSA-P patients exhibited compromised force coordination, including negative load forces and variable grip forces.
Conclusions:
- Individuals with MSA-P demonstrate bradykinesia and impaired coordination of motor components essential for object transport.
- These findings highlight sensorimotor control deficits as a key characteristic of MSA-P affecting daily activities.