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[Epidermal growth factor receptor in conjunctiva]
1Department of Ophthalmology, School of Medicine, Tokai University, Isehara, Japan.
Abstract:
Epidermal growth factor receptor (EGFR) was studied in conjunctiva. Two specimens of normal conjunctiva and eleven of diseases ones, consisting of 2 pingueculas, 4 healing traumatic conjunctiva , and 5 proliferative disorders, were studied immunohistochemically using rabbit anti-human EGFR antibody with avitin-biotin and diaminobentizin method. These investigations revealed that the immunoreactive EGFR was identified only in the conjunctiva of 2 of the 3 cases of granuloma following pterygium surgery but not in the other specimens, including the normal conjunctiva. This fact suggests that abnormal expression of the EGFR could play a role in pathological status of conjunctiva.
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