Related Experiment Video
Updated: Aug 15, 2026
Oral Biofilm Formation on Different Materials for Dental Implants
Published on: June 24, 2018
Detection and measurements of soluble intercellular adhesion molecules at implants and teeth: a comparative study
Ceyda Oezcakir1, Mohammed Fekry-Khedr, Regina Mericske-Stern
1Department of Prosthodontics, University of Bern, Bern, Switzerland.
Background:
Adhesion molecules on endothelial cells and in the periodontal tissues control the immigration and retention of cells. The level of soluble intercellular adhesion molecules (sICAMs) has been used as a marker of the severity and/or extent of the inflammatory process in a wide range of pathologies, including periodontitis.
Purpose:
This study was designed to detect and compare sICAM-1 at teeth and implants in relation to clinical periodontal and periimplant parameters.
Method:
Regular recall patients with (1) implants and teeth, (2) implants, and (3) teeth were examined. Samples of sulcus fluid were collected from teeth and implants. The concentration of sICAM-1 was measured by enzyme-linked immunoabsorbent assay. Periodontal parameters were recorded after sampling.
Results:
The range of measured sICAM-1 was large (from below 100 to 1,200 ng/mL). The concentration of sICAM-1 was not different for teeth and implants but was significantly elevated in sites with positive bleeding on probing (BoP), namely, 571 ng/mL at teeth and 529 ng/mL at implants compared with 150 ng/mL and 169 ng/mL, respectively, with negative BoP. The regression analysis showed that the concentration of sICAM-1 was highly associated with positive BoP but was not dependent on the fluid volume.
Conclusions:
A similarity of the sulcus fluid at teeth and implants was observed with regard to the detection of sICAM-1.
