Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic polymorphism and TH1/TH2 orientation.

N Bottini1, F Gloria-Bottini, A Amante

  • 1Department of Orthopedic Surgery and the Institute of Genetic Medicine, Unversity of Southern California, Los Angeles, CA, USA.

International Archives of Allergy and Immunology
|October 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Draft Genome Sequence of Streptococcus agalactiae TA B490, a Multidrug-Resistant Strain Isolated from Bovine Mastitis in Argentina.

Microbiology resource announcements·2021
Same author

Severe endometriosis: low value of AMH did not affect oocyte quality and pregnancy outcome in IVF patients.

European review for medical and pharmacological sciences·2020
Same author

Different distribution of antimicrobial resistance genes and virulence profiles of Staphylococcus aureus strains isolated from clinical mastitis in six countries.

Journal of dairy science·2020
Same author

Is there a relationship between stature and age of onset of type 2 Diabetes?

Diabetes & metabolic syndrome·2019
Same author

Smoking and hypertension: Effect of adenosine deaminase polymorphism.

Clinical and experimental hypertension (New York, N.Y. : 1993)·2018
Same author

The relationship between p53 codon 72 genetic polymorphism and sperm parameters. A study of men with varicocele.

Reproductive medicine and biology·2017
Same journal

Differences in Reported Anaphylaxis Associated With Common Nonsteroidal Anti-inflammatory Drugs: A Pharmacovigilance Study.

International archives of allergy and immunology·2026
Same journal

Association of Serum Galectin-3 Binding Protein with Acute Exacerbation, Inflammation, and Airway Remodeling in Pediatric Asthma.

International archives of allergy and immunology·2026
Same journal

Effectiveness of a Provincial Law to Improve Epinephrine Use for Anaphylaxis in Schools in Alberta, Canada: A Pre-Post Study.

International archives of allergy and immunology·2026
Same journal

Rab27 a regulates dendritic cell immune tolerogenic capacity.

International archives of allergy and immunology·2026
Same journal

Burden of Hereditary Angioedema in Adults: Impact of Disease and Patient Characteristics.

International archives of allergy and immunology·2026
Same journal

Predictors of Treatment Response to Omalizumab in Children with Chronic Spontaneous Urticaria: A Real World Study.

International archives of allergy and immunology·2026
See all related articles

Genetic factors influence Th1/Th2 immune responses. This study found opposite association patterns for specific genetic polymorphisms in bronchial asthma (Th2) and Crohn's disease (Th1), supporting a role in immune orientation.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Human Genetics

Background:

  • Genetic factors are implicated in T-helper cell type 1 (Th1)/T-helper cell type 2 (Th2) immune response orientation.
  • Genetic variations may confer differential susceptibility to Th1- and Th2-associated diseases.

Purpose of the Study:

  • To investigate the association patterns of specific genetic polymorphisms with Th2-biased bronchial asthma and Th1-biased Crohn's disease.
  • To determine if genetic factors contribute to the orientation of Th1/Th2 immune responses.

Main Methods:

  • Comparative analysis of four genetic polymorphisms (haptoglobin, adenosine deaminase (ADA), acid phosphatase locus 1 (ACP1), MN) in Roman children with bronchial asthma (n=291) and adult Romans with Crohn's disease (n=72).
  • Phenotype determination for selected genetic markers.

Related Experiment Videos

  • Analysis of gametic type distribution differences between disease groups and controls.

    • Main Results:

    • The pattern of phenotype association with bronchial asthma was opposite to that observed in Crohn's disease when compared to controls.
    • Analysis of ACP1, ADA, and MN polymorphisms revealed opposing association patterns between bronchial asthma and Crohn's disease relative to controls.

    Conclusions:

    • The observed opposing association patterns support the hypothesis that certain genetic systems contribute to Th1/Th2 immune orientation.
    • Genetic polymorphisms in ACP1, ADA, and MN may play a role in directing Th1/Th2 immune responses and influencing disease susceptibility.