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Updated: Aug 2, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Biphasic interaction of gamma-globulin with copper cations
S B Cheknev1, E E Babaeva, M S Zharkova
1Laboratory of Cell-Cell Interactions, NF Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow. cheknev@riem.ru
Abstract:
Interactions of human serum gamma-globulin with copper cations in solution were studied by differential ultraviolet spectrophotometry. Copper in supraphysiological concentrations increases optical density of protein solution, reflecting the effect of gamma-globulin saturation with metal. In physiological and lower concentrations of copper cations we observed hypochromia in the protein absorption spectrum. Conformational changes in g-globulin molecule during interactions with copper by the surface and intramolecular binding sites and possible role of bivalent metal cations in the maintenance of certain conformations of immunoactive serum proteins are discussed.
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