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Assessing a minimal executive operation in schizophrenia.
Marie-Laure Grillon1, Marcia K Johnson, Jean-Marie Danion
1INSERM 0117, Service Hopitalo-Universitaire de Santé Mentale et Thérapeuthique, Hôpital Sainte-Anne, Université Paris V, Paris, France.
Psychiatry Research
|October 18, 2005
Summary
Patients with schizophrenia showed impaired verbal response times in a memory refreshing task. However, they still benefited from memory refreshing for long-term accuracy and recollection.
Area of Science:
- Cognitive psychology
- Neuroscience
- Clinical psychology
Background:
- Schizophrenia is associated with cognitive deficits, impacting memory processes.
- Understanding specific cognitive operations like stimulus refreshing is crucial for characterizing these deficits.
Purpose of the Study:
- To investigate the cognitive operation of stimulus refreshing in patients with schizophrenia.
- To compare verbal response times and recognition memory between schizophrenia patients and healthy controls during a refreshing task.
Main Methods:
- Participants performed a word recognition task involving reading, immediate repetition, and refreshing.
- Verbal response times were recorded for each condition.
- Recognition memory was assessed using Remember, Know, and Guess responses.
Main Results:
- Patients with schizophrenia exhibited slower verbal response times specifically in the refreshing condition compared to controls.
- While overall recognition memory was poorer in patients, the benefit of refreshing on long-term memory accuracy and recollection (Remember responses) was preserved.
- Patients derived less familiarity benefit from repeated exposure compared to refreshing.
Conclusions:
- Schizophrenia patients may struggle to engage the stimulus refreshing process effectively.
- Despite potential difficulties, inducing stimulus refreshing still yields significant long-term memory benefits in patients with schizophrenia.