Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bottom-up and top-down dynamics in visual cortex.

James Schummers1, Jitendra Sharma, Mriganka Sur

  • 1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Progress in Brain Research
|October 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Internal state dynamically gates task-specific attractor dynamics in prefrontal cortex.

bioRxiv : the preprint server for biology·2026
Same author

Decomposing the modulation of interactions between neuronal populations.

bioRxiv : the preprint server for biology·2026
Same author

Functional organization of dendritic spines in mouse visual cortex layer 2/3 neurons.

iScience·2026
Same author

Behavioral phenotypes and neuronal biomarkers in F1 mutant macaque model of SHANK3-associated autism spectrum disorders.

Neuron·2026
Same author

CHARIOT-AAV: Conjugation of diverse vectors to adeno-associated viruses for delivery of large genes.

bioRxiv : the preprint server for biology·2026
Same author

Isolated Congenital Facial Nerve Aplasia in a 13-Year-Old Child: Imaging Findings and Long-Term Functional Adaptation.

Cureus·2026
Same journal

Preface.

Progress in brain research·2025
Same journal

Mindfulness and meditation: Promoting emotional and cognitive health.

Progress in brain research·2025
Same journal

Cognitive stimulation enhancing memory and mental function.

Progress in brain research·2025
Same journal

The science behind non-pharmacological interventions.

Progress in brain research·2025
Same journal

Technology-assisted interventions for neuropsychiatric disorders.

Progress in brain research·2025
Same journal

Ethical consideration in non-pharmacological treatments for neuropsychiatric disorders.

Progress in brain research·2025
See all related articles

The adult visual cortex (V1) exhibits rapid plasticity, allowing orientation tuning to adapt to visual input. This dynamic process, crucial for natural vision, enhances orientation discrimination and guides eye movements.

Area of Science:

  • Neuroscience
  • Visual Cortex Plasticity
  • Sensory Information Processing

Background:

  • Orientation selectivity in the primary visual cortex (V1) is a fundamental property.
  • Adult V1 networks display significant bottom-up and top-down plasticity.
  • The balance of excitatory and inhibitory synaptic inputs shapes orientation tuning.

Purpose of the Study:

  • To investigate the mechanisms underlying orientation tuning creation and maintenance in V1.
  • To explore the dynamics of orientation plasticity in response to visual stimuli.
  • To understand how V1 contributes to natural vision and decision-making.

Main Methods:

  • Intracellular measurements of synaptic conductances in V1.
  • Adaptation experiments using oriented visual stimuli in V1 of adult animals.

Related Experiment Videos

  • Analysis of V1 neuronal responses in behaving monkeys during visual tasks.

    • Main Results:

    • Excitation and inhibition are balanced across V1, critical at pinwheel centers.
    • Short-term exposure to oriented stimuli reversibly shifts V1 neuron orientation tuning, especially near pinwheel centers.
    • Adaptation sharpens orientation tuning, improving orientation discrimination and signaling internal representations for guiding eye movements.

    Conclusions:

    • V1 exhibits rapid, experience-dependent plasticity that refines orientation selectivity.
    • This plasticity is essential for adapting to natural vision and improving visual perception.
    • V1 neurons play a role in Bayesian updating and guiding behavior based on learned information.